Competitive inhibition of a glutamate carboxypeptidase by phosphonamidothionate derivatives of glutamic acid. |
| |
| Authors: | C E Rodriguez H Lu T T Dinh K L Mlodnosky A Dastgah V Q Lam C B Nichols C E Berkman |
| |
| Affiliation: | Department of Chemistry & Biochemistry, San Francisco State University, CA 94132, USA. |
| |
| Abstract: | Several N-thiophosphonyl-glutamates were found to be potent competitive inhibitors of a zinc-dependent glutamyl hydrolase, carboxypeptidase G (CPG). Weak inhibition exhibited by an analogous N-phosphonyl-glutamate suggests that the enhanced potency of the phosphonamidothioates is due to the presence of their sulfur ligand and its favorable interactions with active site features, presumably zinc(II). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
