Distribution of anti-histone-antibody-secreting cells in NZB/NZW mice |
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Authors: | J P Portanova B L Kotzin E A Coleman H N Claman |
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Affiliation: | 1. Division of Clinical Immunology, University of Colorado Health Sciences Center, Denver, Colorado 80262, U.S.A.;1. Division of Clinical Immunology, Veterans Administration Hospital, Denver, Colorado 80262 U.S.A. |
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Abstract: | Using a histone-specific plaque assay, we examined anti-histone-antibody (AHA) production at the organ level in the autoimmune NZB/NZW strain. The spleen had the highest absolute numbers of AHA-secreting cells. High percentages of immunoglobulin-secreting cells producing AHA were characteristic of spleen and bone marrow but not lymph node. AHA-secreting cells were detected in NZB/NZW mice with elevated serum activity but not in mice with normal serum levels. Serum AHA activity correlated with the number of AHA-secreting cells in the spleen but not with the total number of immunoglobulin-secreting cells in the spleen nor with the total serum immunoglobulin level. These findings concerning the organ distribution of AHA-secreting cells contrast with results of other investigators studying autoantibodies of other specificities. Furthermore, our results suggest that AHA production does not solely result from a generalized increase in total immunoglobulin synthesis present in NZB/NZW mice. |
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