Synthesis of estradiol-pheophorbide a conjugates: evidence of nuclear targeting, DNA damage and improved photodynamic activity in human breast cancer and vascular endothelial cells. |
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Authors: | Naram El-Akra Arielle Noirot Jean-Charles Faye Jean-Pierre Souchard |
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Institution: | Laboratoire des Interactions Moléculaires et Réactivités Chimiques et Photochimiques, Université Paul Sabatier, 118 Rte de Narbonne, Toulouse Cedex 9, F-31062. |
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Abstract: | The synthesis, physico-chemical properties, cellular localization and photocytotoxicity of estradiol-pheophorbide a conjugates in estrogen-dependent cancer and vascular endothelial cells are described with the aim of increasing the photodynamic activity by targeting the nucleus of both tumor and blood vessel cells. |
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