|
|||||
|
|
Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex |
|
| Authors: | Lucilene D. Mello Emerson S. Ribeiro Lauro T. Kubota Sofi K. C. Elmroth Regina M. S. Pereira |
| Affiliation: | 1. Centro de Ciências Exatas e Tecnológicas, Universidade Federal do Pampa, Campus Bagé, Bage, RS, Brazil 2. Departamento de Química Inorganica, UFRJ, Instituto de Química, Rio de Janeiro, RJ, Brazil 3. UNICAMP, Instituto de Química, P.O. Box 6154, 13083-970, Campinas, SP, Brazil 4. Biochemistry, Chemical Center, Lund University, P.O. Box 124, 221 00, Lund, Sweden 5. Pós-gradua??o em Farmácia, UNIBAN, Rua Maria Candida, 1813, Vila Guilherme, S?o Paulo, SP, Brazil |
| Abstract: | The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)2]2+ with DNA was investigated by DPV and 1H-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)2]2+. In addition, the 1H-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated. |
| Keywords: | DNA Platinum Transition metal complexes DNA– metal complex interaction |
| 本文献已被 SpringerLink 等数据库收录！ | |