| 3-磷酸肌醇依赖性蛋白激酶1结构和功能 |
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| 引用本文： | 刘革修. 3-磷酸肌醇依赖性蛋白激酶1结构和功能[J]. 生命科学, 2005, 17(5): 387-391 |
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| 作者姓名： | 刘革修 |
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| 作者单位： | 暨南大学医学院血液病研究所,广州,510632 |
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| 基金项目： | 暨南大学引进优秀人才基金（No.51204001） |
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| 摘 要： | PDK1可调节AGC激酶家族中一些重要蛋白激酶。这些激酶包括蛋白激酶B（PKB／Akt）、p70核小体S6激酶（p70 ribosomal S6 kinase，S6K）、血清和糖皮质激素诱导激酶（SGK）和蛋白激酶C（PKC）等，它们在细胞代谢、生长、增殖和存活等生理过程中具有重要作用。因此，了解PDK1生物学特性可能对其调节的AGC激酶持续活化的癌症治疗具有一定推动作用。本文对PDK1的结构、遗传和生化特点进行了综述。
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| 关 键 词： | 3-磷酸肌醇依赖性蛋白激酶1 结构 功能 |
| 文章编号： | 1004-0374（2005）05-0387-05 |
| 收稿时间： | 2005-03-08 |
| 修稿时间： | 2005-03-08 |
Structure and function of 3-phosphoinositide-dependent protein kinase-1 |
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| LIU Ge-Xiu. Structure and function of 3-phosphoinositide-dependent protein kinase-1[J]. Chinese Bulletin of Life Sciences, 2005, 17(5): 387-391 |
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| Authors: | LIU Ge-Xiu |
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| Affiliation: | Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, China |
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| Abstract: | Many researches confirm that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is the master regulator of PKA, PKG and PKC-related (AGC) kinases such as isoforms of protein kinase B (PKB)/Akt, p70 ribosomal S6 kinase (S6K), serum- and glucocorticoid-induced protein kinase (SGK) and protein kinase C (PKC), which play important roles in regulating physiological processes relevant to metabolism, growth, proliferation and survival. Knowledge of PDK1 is benefit for the treatment of cancers in which the PDK1-regulated AGC kinases are constitutively activated. Here, we review recent structural and functional studies on PDK1. |
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| Keywords: | 3-phosphoinositide-dependent protein kinase-1 structure function |
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