Gene dosage effect in human triploid fibroblasts |
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| Authors: | C. Junien H. Rubinson J. C. Dreyfus M. C. Meienhofer N. Ravise J. Boué A. Boué |
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| Affiliation: | (1) Institut de Pathologie Moléculaire, Paris, France;(2) Groupe de Recherche de Biologie Prénatale, Centre International de l'Enfance, Paris, France |
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| Abstract: | Summary The activity of 13 cytoplasmic enzymes has been determined in fibroblast extracts from 9 triploid and 13 control lines. The results show a high activity for 2 X-linked enzymes, glucose 6-phosphate dehydrogenase and phosphoglycerate kinase. These data, together with cytogenetic observations, support the contention that 2 X chromosomes were active in the triploid lines.Abbreviations G6PD Glucose 6-phosphate dehydrogenase - 6PGD 6-phosphogluconate dehydrogenase - HK hexokinase - PGM phosphoglucomutase - PHI phosphohexoisomerase - PFK phosphofructokinase - ALD aldolase - TPI triosephosphate isomerase - PGK phosphoglycerate kinase - ENOL enolase - AK adenylate kinase - LDH lactic dehydrogenase - HBDH  hydroxybutyrate dehydrogenaseINSERM U. 129.INSERM U. 73. |
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