Reversion in vivo after inoculation of a molecular proviral DNA clone of simian immunodeficiency virus with a cytotoxic-T-lymphocyte escape mutation |
| |
Authors: | Kobayashi Masahiro Igarashi Hiroko Takeda Akiko Kato Moriaki Matano Tetsuro |
| |
Institution: | Department of Microbiology, Graduate School of Medicine, The University of Tokyo, Japan. |
| |
Abstract: | Vaccine-based control of the replication of a simian immunodeficiency virus (SIV), SIVmac239, in macaques has recently been shown. In the process of the control, a mutant virus escaping from epitope-specific cytotoxic-T-lymphocyte (CTL) responses was rapidly selected and contained. In this study, we show that the wild-type virus appeared and became predominant in the absence of the epitope-specific CTL after inoculation of naive macaques with a molecular clone DNA of the CTL escape mutant SIV. This is the first report describing reversion in vivo from an inoculated, molecular proviral DNA clone of immunodeficiency virus with a CTL escape mutation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|