Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives |
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| Authors: | Sung Kim Jin Lee Hyun-Jung Suh Myung-Eun Choo Hea-Young Park Lee Sang Kook Park Hyen Joo Kim Choonmi Park Sang Woo Lee Chong-Ock |
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| Affiliation: | College of Pharmacy, Ewha Womans University, Seoul 120-750, South Korea. |
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| Abstract: | A series of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives 8 was synthesized from 6,7-dichlorophthalazine-5,8-dione 5 and evaluated for in vitro cytotoxicity against several human tumor cell lines. Most of the tested compounds showed potential cytotoxic activity considerably higher than that of the reference compounds, ellipticine and doxorubicin. |
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