Conversion of pyridylamino sugar chains to corresponding reducing sugar chains |
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Authors: | Takahashi Chiaki Nakakita Shin-ichi Hase Sumihiro |
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Institution: | Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043. |
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Abstract: | Pyridylamino sugar chains were converted to the corresponding reducing sugar chains by first converting them to 1-amino-1-deoxy derivatives using the method previously reported S. Hase, J. Biochem. 112, 266-268 (1992)] and then converting the products to the corresponding reducing sugar chains using the Sommlet reaction. The reaction conditions were optimized so as to obtain the maximal product yield using 1-amino-1-deoxylactose and 1-amino-1-deoxy-N-acetylglucosamine. When the established procedure was successively applied to pyridylamino high-mannose and complex-type sugar chains, the corresponding reducing sugar chains were obtained in yields of 30%. |
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