多氧霉素及其生物合成的研究进展

多氧霉素(Polyoxins)是高效广谱抗真菌核苷类抗生素,在农业上广泛用于防治植物真菌病害。本文综述了多氧霉素化学结构和理化性质,尤其是武汉大学组合生物合成与新药发现(教育部)重点实验室近年来在该抗生素生物合成基因簇的克隆、生物合成途径的阐明以及多氧霉素组合生物合成等多个方面的研究进展与成果,并对今后以多氧霉素为代表的核苷类抗生素的生物合成研究进行了展望。

Research progress on polyoxins and its biosynthesis

Polyoxin is a high effective and broad-spectrum antifungal peptidyl nucleoside antibiotics inhibiting fungal cell wall biosynthesis, as a result, it was used extensively to control phytopathengenic fungi in agriculture. This review summarized the research progress on the chemical structure and physical and chemical properties of this antibiotic, and particularly described recent advance of our lab on the cloning and elucidation of the polyoxin biosynthetic pathway, as well as the combinatorial biosynthesis of this antibiotic. Simultaneously, we also take a brief perspective on the studies on nucleoside antibiotics biosynthesis.