Charybdotoxin blocks dendrotoxin-sensitive voltage-activated K channels |
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Authors: | H Schweitz C E Stansfeld J N Bidard L Fagni P Maes M Lazdunski |
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Institution: | Centre de Biochimie du Centre National de la Recherche Scientifique, Nice, France. |
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Abstract: | Charybdotoxin, a short scorpion venom neurotoxin, which was thought to be specific for the blockade of Ca2+-activated K+ channels also blocks a class of voltage-sensitive K+ channels that are known to be the target of other peptide neurotoxins from snake and bee venoms such as dendrotoxin and MCD peptide. Charybdotoxin also inhibits 125-dendrotoxin and 125I-MCD peptide binding to their receptors. All these effects are observed with an IC50 of about 30 nM. |
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Keywords: | K+ channel Charybdotoxin Dendrotoxin Mast cell degranulating peptide (Dorsal root ganglia Rat brain) |
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