Enantioselective hydrolysis of insoluble (R,S)-ketoprofen ethyl ester in dispersed aqueous reaction system induced by chiral cyclodextrin |
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| Authors: | Sun-Hwa Kim Tae-Kwon Kim Gab-Sang Shin Kwang-Woo Lee Hyun-Dong Shin Yong-Hyun Lee |
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| Institution: | Department of Genetic Engineering, College of Natural Sciences, Kyungpook National University, Daegu 702-701, South Korea. |
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| Abstract: | The enantioselective hydrolysis of insoluble (R,S)-ketoprofen ethyl ester to the optically active (S)-ketoprofen was carried out in a dispersed aqueous lipase reaction system induced by the inclusion of chiral cyclodextrins for complexation of the substrate. Hydroxypropyl-beta-cyclodextrin was the most effective chiral selector and disperser giving an enantiomeric excess and conversion yield of 0.99 and 0.49, respectively. |
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| Keywords: | chiral cyclodextrin enantioselective hydrolysis lipase (R S)-ketoprofen ethyl ester (S)-ketoprofen |
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