Interleukin-1 receptor antagonist allele (ILIRN*2) associated with nephropathy in diabetes mellitus |
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Authors: | Alexandra I F Blakemore Angela Cox Ana-Maria Gonzalez Joanna K Maskill Marianne E Hughes R Malcolm Wilson John D Ward Gordon W Duff |
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Institution: | (1) Section of Molecular Medicine, Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, S10 2JF Sheffield, UK;(2) Diabetes Centre, Royal Hallamshire Hospital, S10 2JF Sheffield, UK;(3) Present address: Health Research Institue and Division of Biomedical Sciences, Sheffield Hallam University, S1 1WB Sheffield, UK |
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Abstract: | We have previously found association between an allele of the interleukin-1 (IL-1) receptor antagonist gene (ILIRN) and several inflammatory diseases, where IL-1 has been implicated in the inflammatory mechanism. We have now, therefore, tested the association of this specific allele (ILIRN*2) with complications of diabetes which have an inflammatory tissue component. We have tested the allele frequency of ILIRN*2 in 128 patients with insulin-dependent and 125 with non-insulin-dependent diabetes mellitus (NIDDM). There was a significant association between carriage of ILIRN*2 and diabetic nephropathy (P < 0.0001,P
corrected < 0.0012). The association was significant in both types of diabetes, but the observed increase was highest in NIDDM, rising to double the control levels. It appears that ILIRN*2 is a novel genetic marker of severity of inflammatory complications of diseases rather than a marker of disease susceptibility. If the DNA polymorphism is associated with altered gene function, new therapeutic interventions may be possible. |
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