New acyclonucleosides: synthesis and anti-HIV activity |
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| Authors: | Hadj-Bouazza Amel Zerrouki Rachida Krausz Pierre Laumond Géraldine Aubertin Anne Marie Champavier Yves |
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| Affiliation: | Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Université de Limoges, Limoges, France. |
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| Abstract: | The synthesis of new acyclic nucleosides is described. These syntheses were accomplished by various methods: glycosylation, selective or total deprotection, oxidation/reduction, chlorination or azidation of hydroxyl groups. The compounds were characterized with NMR, mass and IR spectroscopy. Antiviral properties of these compounds were evaluated on HIV-1 infected cell lines. |
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