Hematopoietic progenitors express embryonic stem cell and germ layer genes |
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Authors: | Pessac Bernard Bara Mehdi Ait Ford David Patibandla Gopi K Trisler David |
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Affiliation: | a CNRS UMR 8118, université Paris Descartes, 45, rue des Saints-Pères, 75270 Paris cedex 06, France;b Centre de recherche des Cordeliers, UMRS 872, 15, rue de l’École de médecine, 75006 Paris, France;c Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA;d Multiple Sclerosis Center of Excellence, East VAMHCS, Baltimore, MD 21201, USA |
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Abstract: | Cell therapy for tissue regeneration requires cells with high self-renewal potential and with the capacity to differentiate into multiple differentiated cell lineages, like embryonic stem cells (ESCs) and adult somatic cells induced to pluripotency (iPSCs) by genetic manipulation. Here we report that normal adult mammalian bone marrow contains cells, with the cell surface antigen CD34, that naturally express genes characteristic of ESCs and required to generate iPSCs. In addition, these CD34+ cells spontaneously express, without genetic manipulation, genes characteristic of the three embryonic germ layers: ectoderm, mesoderm and endoderm. In addition to the neural lineage genes we previously reported in these CD34+ cells, we found that they express genes of the mesodermal cardiac muscle lineage and of the endodermal pancreatic lineage as well as intestinal lineage genes. Thus, these normal cells in the adult spontaneously exhibit characteristics of embryonic-like stem cells. |
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Keywords: | CD34+ stem cell Pluripotent cell Cell replacement therapy Mesodermal cardiac cell Endodermal pancreatic cellMots clé s: Cellule souche CD34+ Cellule pluripotente Thé rapie cellulaire Cellules cardiaques mé sodermiques Cellules pancré atiques endodermiques |
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