Neuropeptides in human cerebrospinal fluid |
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| Authors: | W H Berrettini J I Nurnberger P W Gold M Chretien G P Chrousos J S Chan L R Goldin E S Gershon |
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| Affiliation: | 1. Clinical Neurogenetics Branch, DIRP, National Institute of Mental Health, Building 10, Rm. 3N220, 9000 Rockville Pike, Washington, D.C. 20205-1000, USA;2. Biological Psychiatry Branch, DIRP, National Institute of Mental Health, Washington, D.C. 20205-1000, USA;3. Clinical Research Institute of Montreal, Montreal, Canada;4. Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Washington, D.C. 20205-1000, USA |
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| Abstract: | Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) were highly, positively correlated with one another. This result is consistent with the hypothesis that cerebrospinal fluid levels of these seven peptides are a function of some common regulatory factor, such as shared release into the cerebrospinal fluid. |
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