1. Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA;2. Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;3. Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;4. Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA;5. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA;6. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Abstract:
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Highlights? Hdac1/2 regulate development of Sox2+ endoderm progenitors ? Bmp4, Rb1, p21, and p16 are direct targets of Hdac1/2 in lung endoderm ? Increased Bmp4 suppresses Sox2 expression in lung endoderm ? Hdac1/2 are required for lung secretory epithelial regeneration
