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Inhibition of Leptin Regulation of Parasympathetic Signaling as a Cause of Extreme Body Weight-Associated Asthma
Authors:Emilio Arteaga-Solis  Tiffany Zee  Charles W Emala  Charles Vinson  Jürgen Wess  Gerard Karsenty
Institution:1. Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA;2. Department of Anesthesia, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA;3. Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA;4. Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;5. Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Abstract:
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  • Highlights? Leptin regulates airway diameter, independently of body weight and inflammation ? Leptin uses the parasympathetic tone to regulate airway diameter ? Modulating the parasympathetic tone can correct bronchoconstriction in obese mice
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