| 皮肤类器官的构建、功能及其应用研究进展 |
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| 引用本文： | 王敏,张临风,徐鹤然,张晓娜,化璟琳,张甜甜,赵风年,朱姿英.皮肤类器官的构建、功能及其应用研究进展[J].生物化学与生物物理进展,2022,49(10):1961-1973. |
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| 作者姓名： | 王敏 张临风 徐鹤然 张晓娜 化璟琳 张甜甜 赵风年 朱姿英 |
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| 作者单位： | 1）北京工商大学化学与材料工程学院，北京 100048;2）北京工商大学-唐颐新型材料安全与评价创新研究中心，北京 102401,1）北京工商大学化学与材料工程学院，北京 100048;2）北京工商大学-唐颐新型材料安全与评价创新研究中心，北京 102401,1）北京工商大学化学与材料工程学院，北京 100048;2）北京工商大学-唐颐新型材料安全与评价创新研究中心，北京 102401,1）北京工商大学化学与材料工程学院，北京 100048;2）北京工商大学-唐颐新型材料安全与评价创新研究中心，北京 102401,1）北京工商大学化学与材料工程学院，北京 100048;2）北京工商大学-唐颐新型材料安全与评价创新研究中心，北京 102401,2）北京工商大学-唐颐新型材料安全与评价创新研究中心，北京 102401,1）北京工商大学化学与材料工程学院，北京 100048;2）北京工商大学-唐颐新型材料安全与评价创新研究中心，北京 102401,3）中国人民解放军总医院创新医学部，北京 100853 |
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| 基金项目： | 北京工商大学青年教师科研启动基金（QNJJ2022-27） 资助项目。 |
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| 摘 要： | 皮肤类器官作为一种新型的类器官模型，不仅能高度模拟皮肤组织的生理结构和功能，更好地在不同体外环境下还原较真实的皮肤生态，还可以应用于皮肤发育研究、皮肤疾病病理研究及药物筛选等领域。在干细胞研究中，皮肤类器官模型可以在特殊的生境下对具有特定功能的皮肤细胞及其附属物进行重建和改造，以弥补现有体外皮肤模型在结构、功能等方面的不足。基于此，皮肤类器官将会在皮肤再生、组织修复、药物筛选及医学美容等方面扮演越来越重要的角色。本文详述了皮肤类器官构建中所参与的细胞来源及近年来的应用，并对未来皮肤类器官的发展与优化做出了展望。
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| 关 键 词： | 皮肤类器官 多能干细胞 皮肤再生 药物筛选 |
| 收稿时间： | 2021/12/29 0:00:00 |
| 修稿时间： | 2022/9/19 0:00:00 |
Research Progress in Establishment, Function and Application of Skin Organoids |
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| WANG Min,ZHANG Lin-Feng,XU He-Ran,ZHANG Xiao-N,HUA Jing-Lin,ZHANG Tian-Tian,ZHAO Feng-Nian and ZHU Zi-Ying.Research Progress in Establishment, Function and Application of Skin Organoids[J].Progress In Biochemistry and Biophysics,2022,49(10):1961-1973. |
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| Authors: | WANG Min ZHANG Lin-Feng XU He-Ran ZHANG Xiao-N HUA Jing-Lin ZHANG Tian-Tian ZHAO Feng-Nian and ZHU Zi-Ying |
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| Institution: | 1)College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China;2)Tangyi Bioengineering Raw Materials Cosmetics Safety and Efficacy Evaluation Technology Joint Innovation Center, Beijing Technology and Business University, Beijing 102401, China,1)College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China;2)Tangyi Bioengineering Raw Materials Cosmetics Safety and Efficacy Evaluation Technology Joint Innovation Center, Beijing Technology and Business University, Beijing 102401, China,1)College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China;2)Tangyi Bioengineering Raw Materials Cosmetics Safety and Efficacy Evaluation Technology Joint Innovation Center, Beijing Technology and Business University, Beijing 102401, China,1)College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China;2)Tangyi Bioengineering Raw Materials Cosmetics Safety and Efficacy Evaluation Technology Joint Innovation Center, Beijing Technology and Business University, Beijing 102401, China,1)College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China;2)Tangyi Bioengineering Raw Materials Cosmetics Safety and Efficacy Evaluation Technology Joint Innovation Center, Beijing Technology and Business University, Beijing 102401, China,2)Tangyi Bioengineering Raw Materials Cosmetics Safety and Efficacy Evaluation Technology Joint Innovation Center, Beijing Technology and Business University, Beijing 102401, China,1)College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China;2)Tangyi Bioengineering Raw Materials Cosmetics Safety and Efficacy Evaluation Technology Joint Innovation Center, Beijing Technology and Business University, Beijing 102401, China,3)Division of Innovative Medical Research, Chinese PLA General Hospital, Beijing 100853, China |
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| Abstract: | As a new type of organoid model, skin organoids can reconstruct and modify different types of cells and appendages with specific functions such as umbilical cord blood stem cells, induced pluripotent stem cells, keratinocytes and fibroblasts, as well as sebaceous glands, sweat gland and hair follicles under special habitats, which can not only highly simulate the physiological structure and function of skin tissues, but also better restoring more realistic skin ecology under different in vitro environments. It can also be used in the fields of skin wound regeneration, skin tumor, immune and metabolic diseases, treatment of inflammatory diseases and drug screening. Meanwhile, skin organoids can not only make up for the deficiencies of existing in vitro skin models in terms of structure and function, but also enable high-throughput screening of drugs or raw materials, reducing the time and economic costs in the later stages of drug screening. However, due to the limitations of current technology, the types and functions of organoids cannot be fully realized to realistically simulate the physiological conditions in the body such as lipid metabolism and blood circulation. Moreover, issues such as consistency and standardization of mass-produced organoids need to be addressed, such as source cells, structure and function, which require the establishment of appropriate standards based on practical applications. Based on this, this paper details the cell sources involved in skin organoids construction and their applications in recent years and several skin appendages like organs that have been constructed and provides an outlook on the future development and optimization of skin organoids. |
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| Keywords: | skin organoid pluripotent stem cells skin regeneration drug screening |
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