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Uncoupling VEGFA Functions in Arteriogenesis and Hematopoietic Stem Cell Specification
Authors:Amy Leung  Aldo Ciau-Uitz  Philip Pinheiro  Rui Monteiro  Jie Zuo  Paresh Vyas  Roger Patient  Catherine Porcher
Institution:1. MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, OX3 9DS Oxford, UK
Abstract:
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  • Highlights? VEGFA short isoform supports endothelial/arterial development of the dorsal aorta ? ETO2 maintains high levels of VEGFA medium and long isoforms in the somites ? VEGFA medium isoform instructs the blood program in blood stem cell precursors ? ETO2 specifies blood stem cells in a non-cell-autonomous manner
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