1. Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies (SOKENDAI), Mishima, Shizuoka 411-8540, Japan;2. Comparative Genomics Laboratory, National Institute of Genetics and The Graduate University for Advanced Studies (SOKENDAI), Mishima, Shizuoka 411-8540, Japan;3. Cell Innovation Project, National Institute of Genetics and The Graduate University for Advanced Studies (SOKENDAI), Mishima, Shizuoka 411-8540, Japan;4. Laboratory of Biological Macromolecules, National Institute of Genetics and The Graduate University for Advanced Studies (SOKENDAI), Mishima, Shizuoka 411-8540, Japan;5. Wellcome Trust Centre for Cell Biology, University of Edinburgh, King’s Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK;6. National Institute of Informatics, Hitotsubashi, Chiyoda-ku, Tokyo 101-8430, Japan;7. Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan
Abstract:
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Highlights? Chromosome engineering efficiently generates neocentromeres in chicken DT40 cells ? CENP-A reproducibly occupies an ～40 kb genomic region at each neocentromere ? Nonkinetochore CENP-A appears to function as a seed for neocentromere assembly
