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Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation

Authors:	Tuo Deng Christopher J Lyon Laurie J Minze Jianxin Lin Jia Zou Joey Z Liu Yuelan Ren Zheng Yin Dale J Hamilton Patrick R Reardon Vadim Sherman Helen Y Wang Kevin J Phillips Paul Webb Stephen TC Wong Rong-fu Wang Willa A Hsueh

Institution:	1. The Methodist Diabetes and Metabolism Institute, Center for Diabetes Research and Center for Inflammation and Epigenetics, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA;2. Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA;3. Department of Surgery, The Methodist Hospital, Houston, TX 77030, USA

Abstract:	Download : Download high-res image (274KB) Download : Download full-size image Highlights? Obesity enhances MHCII expression in primary human and mouse adipocytes ? Adipocytes activate CD4+ ARTs via MHCII and leptin to induce adipose inflammation ? Macrophage changes in adipose follow adipocyte and T cell interactions during HFD ? Adaptive immune mechanisms are essential to obesity-induced adipose inflammation

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