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Tmem64 Modulates Calcium Signaling during RANKL-Mediated Osteoclast Differentiation
Authors:Hyunsoo Kim  Taesoo Kim  Byung-Chul Jeong  Il-Taeg Cho  Daehee Han  Noriko Takegahara  Takako Negishi-Koga  Hiroshi Takayanagi  Jae Hee Lee  Jai-Yoon Sul  Vikram Prasad  Seoung Hoon Lee  Yongwon Choi
Institution:1. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;2. Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA;3. TKM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea;4. Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju 500-757, Korea;5. Department of Cell Signaling, Tokyo Medical and Dental University, Tokyo 113-8549, Japan;6. Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA;7. Departments of Oral Microbiology and Immunology, Wonkwang University School of Dentistry, Iksan 570-749, Korea
Abstract:
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  • Highlights? Tmem64-deficient mice show increased bone volume ? Tmem64 deficiency reduces Ca2+]i oscillation in response to RANKL stimulation ? Tmem64 interacts with SERCA2 ? Tmem64 positively regulates osteoclast formation via SERCA2/Ca2+ signaling
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