1. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA;2. Section of Comparative Medicine, Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT 06520, USA;3. Department of Genetics, Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06520, USA;4. Department of Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
Abstract:
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Highlights? The hexosamine/O-GlcNAc pathway regulates cellular clock oscillation ? OGT promotes expression of BMAL1/CLOCK target genes in cultured cells and liver ? Rhythmic O-GlcNAcylation stabilizes BMAL1 and CLOCK by inhibiting their ubiquitination ? Hepatic manipulation of OGT perturbs the diurnal rhythm of glucose homeostasis
