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Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets
Authors:Florian Wilfling  Huajin Wang  Joel T Haas  Natalie Krahmer  Travis J Gould  Aki Uchida  Ji-Xin Cheng  Morven Graham  Romain Christiano  Florian Fröhlich  Xinran Liu  Kimberly K Buhman  Rosalind A Coleman  Joerg Bewersdorf  Robert V Farese  Tobias C Walther
Institution:1. Department of Cell Biology, Yale School of Medicine, New Haven, CT 06510, USA;2. Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA;3. Department of Nutrition Science, Purdue University, West Lafayette, IN 47907-2059, USA;4. Department of Chemistry, Purdue University, West Lafayette, IN 47907-2059, USA;5. Center for Cellular and Molecular Imaging, Yale School of Medicine, New Haven, CT 06520-8002, USA;6. Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599-7461, USA;7. Departments of Medicine and Biochemistry & Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
Abstract:
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  • Highlights? Triacylglyceride (TG) synthesis is coupled with lipid droplet (LD) growth ? Two LD populations exist: growing LDs, containing TG enzymes, and small LDs ? Specific TG synthesis enzymes move from the ER to LDs through membrane bridges ? LD localization of TG enzymes mediates expansion of a subset of LDs
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