1. Yale Stem Cell Center and Department of Cell Biology, Yale School of Medicine, New Haven, CT 06519, USA;2. Department of Molecular, Cell and Developmental Biology, Yale University, New Haven, CT 06511, USA
Abstract:
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Highlights? Piwi-piRNA complexes bind to numerous piRNA-complementary sequences in the genome ? piRNA is necessary and sufficient to recruit Piwi, HP1, and HMT to its target site ? Piwi deficiency drastically changes the epigenetic landscape in the genome ? The Piwi-piRNA mechanism is a major epigenetic programming mechanism in Drosophila
