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Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting
Authors:Fanny Langlet  Barry E Levin  Serge Luquet  Massimiliano Mazzone  Andrea Messina  Ambrose A Dunn-Meynell  Eglantine Balland  Amelie Lacombe  Daniele Mazur  Peter Carmeliet  Sebastien G Bouret  Vincent Prevot  Bénédicte Dehouck
Institution:1. Laboratory of Development and Plasticity of the Postnatal Brain, Jean-Pierre Aubert Research Centre, Inserm U837, 59000 Lille, France;2. School of Medicine, UDSL, 59000 Lille, France;3. Institut de Médecine Prédictive et de Recherche Thérapeutique, Université Lille Nord de France, 59000 Lille, France;4. Neurology Service, Veterans Affairs Medical Center, East Orange, NJ 07018-1095, USA;5. Department of Neurology and Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA;6. Unit of Functional and Adaptive Biology, EAC 4413 CNRS, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France;7. VIB Vesalius Research Center, University of Leuven, 3000 Leuven, Belgium;8. Neuroscience Program, The Saban Research Institute, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, Los Angeles, CA 90027, USA;9. Université d’Artois, 62800 Liévin, France
Abstract:
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  • Highlights? Fasting induces the plasticity of brain barriers in hypothalamic feeding regions ? Central neuroglucopenia triggers blood-hypothalamus barrier plasticity ? Fasting-induced brain barrier plasticity requires VEGF-A expression in tanycytes ? The tanycytic barrier modulates blood-borne signals access to CNS feeding circuits
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