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Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat,High-Sucrose Diet in Mice
Authors:Brian W Parks  Elizabeth Nam  Elin Org  Emrah Kostem  Frode Norheim  Simon T Hui  Calvin Pan  Mete Civelek  Christoph D Rau  Brian J Bennett  Margarete Mehrabian  Luke K Ursell  Aiqing He  Lawrence W Castellani  Bradley Zinker  Mark Kirby  Thomas A Drake  Christian A Drevon  Aldons J Lusis
Institution:1. Department of Medicine/Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;2. Department of Computer Science, University of California, Los Angeles, Los Angeles, CA 90095, USA;3. Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;4. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;5. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway;6. Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA;7. Department of Chemistry and Biochemistry, University of Colorado Boulder, CO 80309, USA;8. Department of Applied Genomics, Bristol-Myers Squibb, Princeton, NJ 08543, USA;9. Department of Metabolic Diseases-Diabetes Drug Discovery, Bristol-Myers Squibb, Princeton, NJ 08543, USA;10. Department of Atherosclerosis Drug Discovery, Bristol-Myers Squibb, Princeton, NJ 08543, USA;11. Howard Hughes Medical Institute, Boulder, CO, 80309, USA
Abstract:
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  • Highlights? Detailed analysis of diet-induced obesity in more than 100 inbred mouse strains ? Identification of 11 genetic loci associated with obesity and dietary responsiveness ? Significant overlap between mouse loci with human GWAS loci for obesity ? Strain-specific shifts in gut microbiota composition in response to dietary intervention
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