A test of linkage for complex discrete and continuous traits in nuclear families |
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Authors: | Tritchler David Liu Ying Fallah Shafagh |
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Affiliation: | University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9. tritchle@uhnres.utoronto.ca |
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Abstract: | This article presents a score test for genetic linkage in nuclear families which applies to any trait having a distribution belonging to the exponential family, which includes binary and normal distributions, and distributions which are skewed or have nonnormal kurtosis. The specific distribution need not be specified and the method applies to sibships of arbitrary size. Tests of complex genetic effects are given, including unspecified mode of inheritance or additive, dominant, overdominant, and recessive modes of inheritance, covariates, multiple-locus models, including gene-gene interactions, and gene-environment interactions. The relation of our method to the Haseman-Elston methods is studied theoretically and by simulation. |
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Keywords: | Continuous trait Covariates Discrete trait Gene-environment interaction Gene-gene interaction Generalized linear model Linkage analysis |
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