Superoxide-induced deimination of arginine in hematopoietic cells |
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Authors: | P P Kamoun E Schneider M Dy |
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Affiliation: | Laboratoire de Biochimie Génétique, H?pital Necker-Enfants Malades, Paris, France. |
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Abstract: | Murine bone marrow cells can produce citrulline directly from L-arginine without intermediate ornithine. An L-arginine-dependent biochemical pathway synthesizing L-citrulline and nitrate, coupled to an effector mechanism has also been recently demonstrated in murine cytotoxic activated macrophages. We show herein that L-citrulline synthesis in murine bone marrow cells can be induced by the generation of superoxide. It can take place in an arginine-free medium, suggesting the implication of a superoxide-dependent peptidyl arginine deiminase. |
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