Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes |
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Authors: | Takahashi Michiko Takahashi Yutaka Takahashi Kenichi Zolotaryov Fyodor N Hong Kyoung Su Kitazawa Riko Iida Keiji Okimura Yasuhiko Kaji Hidesuke Kitazawa Sohei Kasuga Masato Chihara Kazuo |
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Institution: | Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. |
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Abstract: | To explore a novel adipokine, we screened adipocyte differentiation-related gene and found that TIG2/chemerin was strongly induced during the adipocyte differentiation. Chemerin was secreted by the mature 3T3-L1 adipocytes and expressed abundantly in adipose tissue in vivo as recently described. Intriguingly, the expression of chemerin was differently regulated in the liver and adipose tissue in db/db mice. In addition, serum chemerin concentration was decreased in db/db mice. Chemerin and its receptor/ChemR23 were expressed in mature adipocytes, suggesting its function in autocrine/paracrine fashion. Finally, chemerin potentiated insulin-stimulated glucose uptake concomitant with enhanced insulin signaling in the 3T3-L1 adipocytes. These data establish that chemerin is a novel adipokine that regulates adipocyte function. |
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Keywords: | Adipokine Chemerin Insulin signaling Adipocyte differentiation 3T3-L1 adipocyte Insulin sensitivity |
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