Diterpenes from the leaves of Croton zambesicus |
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| Authors: | Block Sebastien Baccelli Chiara Tinant Bernard Van Meervelt Luc Rozenberg Raoul Habib Jiwan Jean-Louis Llabrès Gabriel De Pauw-Gillet Marie-Claire Quetin-Leclercq Joelle |
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| Affiliation: | Laboratoire de Pharmacognosie, Unité CHAM, Université Catholique de Louvain, UCL 72.30-CHAM, Av. E. Mounier, 72, 1200 Bruxelles, Belgium. |
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| Abstract: | Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3beta-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, beta-sitosterol, alpha-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines. |
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| Keywords: | Croton zambesicus Euphorbiaceae Diterpene Trachylobane Pimarane Cytotoxicity |
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