Beta cell apoptosis in diabetes |
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| Authors: | Helen E Thomas Mark D McKenzie Eveline Angstetra Peter D Campbell Thomas W Kay |
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| Institution: | (1) St. Vincent’s Institute of Medical Research, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia;(2) Department of Medicine, St. Vincent’s Hospital, The University of Melbourne, 41 Victoria Parade, Fitzroy, Melbourne, VIC, 3065, Australia |
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| Abstract: | Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes as well as loss of islets after transplantation. In
type 1 diabetes, beta cells are destroyed by immunological mechanisms. In type 2 diabetes abnormal levels of metabolic factors
contribute to beta cell failure and subsequent apoptosis. Loss of beta cells after islet transplantation is due to many factors
including the stress associated with islet isolation, primary graft non-function and allogeneic graft rejection. Irrespective
of the exact mediators, highly conserved intracellular pathways of apoptosis are triggered. This review will outline the molecular
mediators of beta cell apoptosis and the intracellular pathways activated. |
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