LFG: a candidate apoptosis regulatory gene family |
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Authors: | Lan Hu Temple F Smith Gabriel Goldberger |
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Institution: | (1) Graduate Program in Bioinformatics, Boston University, 24 Cummington Street, Boston, MA 02215, USA;(2) BioMolecular Engineering Research Center, Boston University, 36 Cummington Street, Boston, MA 02215, USA;(3) Department of Psychiatry, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA; |
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Abstract: | The expanding wealth of human, model and other organism’s genomic data has allowed the identification of a distinct gene family
of apoptotic related genes. Most of these genes are currently unannotated or have been subsumed under two questionably related
gene families in the past. For example the transmembrane Bax inhibitor 1 (BI1) motif family has been reported to play a role
in apoptosis and to consist of at least seven mammalian protein genes, GRINA, BI1, Lfg/FAIM2, Ghitm, RESC1/Tmbim1, GAAP/Tmbim4, and Tmbm1b. However, a detailed sequence and phylogenetic analysis shows that only five of these form a clear and unique protein family.
This now provides information for understanding and investigating the biological roles of these proteins across a wide range
of tissues in model organisms. The evolutionary relationships among these genes provide a powerful prospective for extrapolating
to human conditions. |
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