Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency |
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| Authors: | William B Weglicki Richard E Stafford Benjamin F Dickens I Tong Mak Marie M Cassidy Terry M Phillips |
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| Institution: | (1) Department of Medicine, George Washington University Medical Center, 2300 Eye Street NW, 20037 Washington DC, USA;(2) Department of Physiology, George Washington University Medical Center, 2300 Eye Street NW, 20037 Washington DC, USA |
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| Abstract: | The effect of thalidomide on circulating cytokines and myocardial lesion formation was investigated in Mg-deficient rats. After two weeks on a Mg-deficient diet, rats show an increase in circulating levels of tumor necrosis factor-alpha and interleukin 1. Thalidomide (1 mg/day) caused a complete inhibition of the increase in circulating tumor necrosis factor-alpha levels, without having an effect on interleukin 1. However, a marked increase in cardiomyopathic lesion formation was observed in Mg-deficient animals treated with thalidomide; possible mechanisms for thalidomide's enhancement of myocardial injury are discussed. (Mol Cell Biochem129: 195–200, 1993) |
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| Keywords: | magnesium-deficiency rats tumor necrosis factor thalidomide interleukin-1 myocardial necrosis |
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