Release of Iron from Ferritin by 6-Hydroxydopamine Under Aerobic and Anaerobic Conditions |
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Authors: | H. N. Lode G. Bruchelt A. G. Rieth D. Niethammer |
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Affiliation: | a Children's Hospital, Dept. Hematology and Oncology, University of Tuebingen, Tuebingen, FRG |
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Abstract: | 6-hydroxydopamine (6-OHDA) proved to be a very effective agent for iron release from ferritin. Iron release was enhanced in the presence of SOD, catalase and under anaerobic conditions. Ascorbic acid, a well known agent able to release iron from ferritin, increased the amount of released iron in more than an additive manner when used in combination with 6-OHDA. Similar to 6-OHDA, 6-hydroxydopa (Topa) and 1,2,4-benzenetriol were also able to release iron in large amounts; in contrast, catecholamines and other benzenediols were comparatively ineffective. |
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Keywords: | 6-Hydroxydopamine ferritin iron release ascorbic acid neuroblastoma |
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