对安贞医院革兰阴性杆菌的耐药趋势调查

目的分析安贞医院感染菌中，居前5位的革兰阴性杆菌的耐药趋势，为临床合理使用抗生素提供必要依据。方法对2000～2002年该院分离的医院感染菌株中，居前5位的革兰阴性杆菌的耐药性，进行回顾性分析。结果革兰阴性杆菌中前5位细菌，对3代头孢菌素的耐药性增高。大多数细菌对亚胺培南和美洛培南敏感。阿米卡星的耐药性有所下降。大肠埃希菌对喹诺酮类抗生素耐药率在85％以上。结论不规范使用抗生素，使细菌的耐药性越来越高，交替使用抗生素可能是降低细菌对抗生素耐药性的有效方法。医院应宏观控制使用抗生素。

Research the direction of the drug resistance of Gram-negative bacteria in recent years

Objective To analysis the drug resistance of gram negative bacteria that was the major bacteria in hospital infection in the past three years,and tried to offer a basis for the use of antibiotics. Method Analysised the drug resistance of the first five gram negative bacteria in hospital infection from 2000 to 2003.Results The resistance of the first five gram negative bacteria to ciprofloxacin were high.Most 12345bacilli were high sensitivity to Imipenem.The drug resistance to Amicacin was declined.Resistance rate of Escherichia to ofloxacin was 85%.Conclusion Overuse of antibiotics made the bacilli resistance to antibiotics were up and up.Controled or spelled antibiotics might be help to reduce the bacilli resistance to antibiotics.