Oriented loading of FtsK on KOPS |
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Authors: | Bigot Sarah Saleh Omar A Cornet François Allemand Jean-François Barre François-Xavier |
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Institution: | Laboratoire de Microbiologie et de Génétique Moléculaire, CNRS UMR5100, Toulouse, France. |
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Abstract: | In Escherichia coli, the ATP-dependent DNA translocase FtsK transports DNA across the site of cell division and activates recombination by the XerCD recombinases at a specific site on the chromosome, dif, to ensure the last stages of chromosome segregation. DNA transport by FtsK is oriented by 8-base-pair asymmetric sequences ('KOPS'). Here we provide evidence that KOPS promote FtsK loading on DNA and that translocation is oriented at this step. |
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