Theoretical treatment of helix–coil transition of complexes DNA with two different ligands having different binding parameters |
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| Authors: | Armen T Karapetian Zareh A Grigoryan Yevgeni Sh Mamasakhlisov Mikayel V Minasyants Poghos O Vardevanyan |
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| Institution: | 1. Department of Physics and Electric Engineering, Yerevan State University of Architecture and Construction, Yerevan 0009, Armenia;2. Departament of Electronics, Goris State University, Avangard 2, Goris, 3201, Armenia;3. Department of Molecular Physics, Yerevan State University, Aleq Manukyan 1, Yerevan 0025, Armenia;4. Department of Biophysics, Yerevan State University, Aleq Manukyan 1, Yerevan 0025, Armenia |
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| Abstract: | The melting transition of DNA–ligand complexes, allowing for two binding mechanisms to different DNA conformations is treated theoretically. The obtained results express the behavior of the experimentally measurable quantities, degree of denaturation, and concentrations of bound ligands on the temperature. The range of binding parameters is obtained, where denaturation curves become multiphasic. The possible application to the nanocomposites crystallization is discussed. |
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| Keywords: | DNA binding parameters degree of denaturation DNA–ligand complexes helix–coil transition |
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