Synthesis and biological evaluation of novel angular fused Pyrrolocoumarins |
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Authors: | Kontogiorgis Christos Litinas Konstantinos E Makri Aristea Nicolaides Demetrios N Vronteli Anastasia Hadjipavlou-Litina Dimitra J Pontiki Eleni Siohou Asimoula |
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Affiliation: | Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece. |
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Abstract: | Angular pyrrolocoumarins were synthesized from the reaction of 4-hydroxyindole or 5-hydroxyindole with DMAD and PPh(3) and were tested for anti-inflammatory and antioxidant activity. These compounds significantly inhibited the carrageenin-induced paw edema (60.5%-73.4%) and have important scavenging activity. Although their interaction with the free stable radical DPPH is not high, compound 9 is the most potent (73.4%) in the in vivo experiment. Compound 7 seems to be a potent LOX inhibitor. An attempt was made to correlate the biological results with their structural characteristics and physicochemical parameters. |
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