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Simulated-microcarrier motion and its effect on radial medium transfer inside a horizontally rotating cylindrical bioreactor (HRCB) for animal cell culture |
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| Authors: | B delos Santos N Shiragami H Unno H Honda M Kariya |
| Institution: | (1) Department of Bioengineering, Tokyo Institute of Technology, Nagatsuta-cho 4259, 227 Midori-ku, Yokohama, Japan;(2) Department of Biotechnology, Faculty of Engineering, Nagoya University Furo-cho, 464 Chikusa-ku, Nagoya, Japan;(3) Japan Synthetic Rubber Co., Inc. Ltd., Tsukuba Research Laboratory, 305 Tsukuba, Ibaraki, Japan |
| Abstract: | The motion and distribution of microcarriers inside a horizontally rotating cylindrical bioreactor were simulated using spherical ion exchange resin particles. Particle motion deviated much from that expected under ideal conditions. The possible mass transfer enhancing effects of particle translation and cluster rotation are discussed. |
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