"On" and "Off" Responses of K+-Induced Synaptosomal Proline Release: Involvement of the Sodium Pump |
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Authors: | Victor J Nickolson |
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Institution: | Medical Biological Laboratory TNO, Rijswijk, The Netherlands |
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Abstract: | The K+-induced release of the putative neurotransmitter proline in rat cerebral cortex synaptosomes was studied by measuring 5-3H]proline released upon exposure to high-K+ media. In contrast to previous experiments, K+ was not substituted for Na+, which was held constant. Under the resulting conditions of increased osmolarity, two peaks of proline release were obtained, one upon exposure to increased K+], another upon restoring normal K+]. The dependence of the latter peak on ionic composition of the medium, and its sensitivity to ouabain are discussed. |
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Keywords: | Proline Putative neurotransmitters Sodium pump Ouabain sensitivity |
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