The nuclear glutathione and its functions |
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| Authors: | V. I. Kulinsky L. S. Kolesnichenko |
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| Affiliation: | 1.Department of Biochemistry,Irkutsk State Medical University,Irkutsk,Russia;2.Department of Bioinorganic and Bioorganic Chemistry,Irkutsk State Medical University,Irkutsk,Russia |
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| Abstract: | During recent years the nuclear localization of glutathione has been confirmed and this fraction has been quantitatively determined. The nuclear GSH and the enzymes of its metabolism realize independent and important functions. They considerably differ from functions of hyaloplasmic and mitochondrial GSH. Glutathione interacts with regulatory pathways, involved into signal transmission into the nucleus. |
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