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Development of L-689,065 - the prototype of a new class of potent 5-lipoxygenase inhibitors |
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| Authors: | J H Hutchinson P Prasit L Y Choo D Riendeau S Charleson J F Evans H Piechuta R G Ball |
| Institution: | a Medicinal Chemistry, Rahway, N.J., U.S.A. b Biochemistry, Rahway, N.J., U.S.A. c Pharmacology, Rahway, N.J., U.S.A. d Biophysical Chemistry, Rahway, N.J., U.S.A. Merck Frosst Centre for Therapeutic Research P.O. Box 1005, Pointe Claire-Dorval, Quebec, H9R 4P8 Canada |
| Abstract: | The combination of a 5-phenylpyridine substituent and a novel, substituted thiopyrano2,3,4-c,d]indole ring system yields a potent and selective 5-lipoxygenase inhibitor, L-689,065. |
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