A novel role for macrophage: antigen discrimination of distinct carbohydrate bonds. |
| |
| Authors: | R M Gorczynski S MacRae J J Jennings |
| |
| Institution: | 1. Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 500 Sherbourne Street, Toronto, Ontario, M4X 1K9, Canada;7. Division of Rheumatology, Henry Ford Hospital, Detroit, Michigan 48202 U.S.A.;2. Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48202 U.S.A. |
| |
| Abstract: | Velocity sedimentation-derived subpopulations of peritoneal exudate macrophages have been pulsed with a variety of TNP-coupled carbohydrate/protein antigens and investigated for their ability to present those antigens in immunogenic form to whole spleen cell populations. The data presented indicate that while no difference is seen in the ability of the various subpopulations examined to present protein antigens for an antibody response, different cells are certainly involved in the antigen handling of carbohydrate antigens for an antibody response. Moreover, it seems that individual macrophage subpopulations can only interact with certain subpopulations of B lymphocytes to induce antibody responses to the same immunogenic determinants. |
| |
| Keywords: | To whom all correspondence should be addressed |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
