Mechanisms of pathogenicity in mycobacteria |
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Authors: | N Rastogi H L David |
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Affiliation: | Unité de la Tuberculose et des Mycobactéries, Institut Pasteur, Paris, France. |
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Abstract: | The purpose of this article is to review current knowledge about the mechanisms of pathogenicity of mycobacteria. The following aspects of the problem are discussed: chemically-defined compounds implicated in the mechanisms of pathogenicity; location in the cell wall of these compounds and their biological activities; mechanisms of intracellular survival of pathogenic mycobacteria as compared to intracellular killing of non-pathogenic mycobacteria; and pathogenesis of mycobacterial infection. The future prospects in the elucidation of the mechanisms of pathogenicity and their possible application for a better control of mycobacterial diseases are briefly discussed. |
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