The Novel Antibacterial Peptide Ceratotoxin A Alters Permeability of the Inner and Outer Membrane of Escherichia coli K-12 |
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| Authors: | Laura Marri Romano Dallai Daniela Marchini |
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| Affiliation: | (1) Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Via Laterina 8, 53100 Siena, Italy , IT;(2) Dipartimento di Biologia Evolutiva, Università di Siena, Via P.A. Mattioli 4, 53100 Siena, Italy , IT |
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| Abstract: | Ceratotoxins are antibacterial 3-kDa amphiphilic peptides isolated from the female reproductive apparatus of the medfly Ceratitis capitata. The antibacterial activity of a chemically synthesized ceratotoxin A (ctx A) has been investigated. Ctx A was mainly active against Gram-negative organisms, and it had a lytic effect on nongrowing Escherichia coli K-12. Data showed that ctx A alters both the outer and the inner membrane of E. coli K-12 cells. Received: 4 August 1995 / Accepted: 2 January 1996 |
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