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Thiol addition to protected allyl glycosides: An improved method for the preparation of spacer-arm glycosides |
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| Authors: | Paul B van Seeventer Johannes ALM van Dorst John F Siemerink Johannis P Kamerling Johannes FG Vliegenthart |
| Institution: | Bijvoet Center, Department of Bio-Organic Chemistry, Utrecht University, P.O. Box 80.075, NL-3508 TB, Utrecht, The Netherlands |
| Abstract: | A useful method for the preparation of differently functionalized sulfide spacer-arm glycosides is presented. Several protected allyl glycosides were variously elongated via a radical addition reaction with pentanethiol, methyl 3-mercaptopropionate, or 2-mercaptoethanol. The hydroxyl function of protected 3-(2-hydroxyethylthio)propyl glycosides was subsequently transformed into an azide function. |
| Keywords: | Neoglycoconjugates Allyl glycosides Sulfide spacer-arm 3-(2-Azidoethylthio)propyl glycosides |
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