Screening the genome to detect an association with hypertension |
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Authors: | Atkinson Elizabeth J de Andrade Mariza |
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Institution: | Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA. atkinson@mayo.edu |
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Abstract: | We report tree-based association analysis as applied to the two Framingham cohorts and to the first replication of the simulated data obtained from the Genetic Analysis Workshop 13. For this analysis, familial association is ignored. The two endpoints examined are hypertension status at initial visit and time-to-hypertension, using a censored data approach. Although linkage association has previously been reported with hypertension, we found no association using the tree-based methodology. |
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