E-rosette receptors induced by phytohemagglutinin on human K cells expressing T-cell surface antigens. |
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| Authors: | E W Ades P Dougherty S L Shore C M Balch |
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| Affiliation: | 1. Cellular Immunobiology Unit of the Tumor Institute, Departments of Microbiology and Surgery, the Comprehensive Cancer Center, University of Alabama Medical Center, Birmingham, Alabama 35294, U.S.A.;2. Clinical Immunology Laboratory, Center for Disease Control, Public Health Service, U.S. Department of Health, Education and Welfare, Atlanta, Georgia 30333 U.S.A. |
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| Abstract: | Killer cells (K cells) enriched from human blood mononuclear cells which mediate antibody-dependent cellular cytotoxicity (ADCC) were examined for surface markers. Sixty-seven percent of the E-rosette-negative, sIg-negative cells reacted with anti-T cell serum (AMT) previously shown to react with immunochemically defined T-cell antigens. Phytohemagglutinin induced 25% of K cells to express an E-rosette receptor. When these induced cells were isolated, greater than 98% reacted with AMT and 17% expressed the Fc receptor for IgG. Furthermore, they retained their functional capacity in ADCC. These findings demonstrate that an E-rosette receptor can be induced on human K cells. The data suggest the K-cell fraction included a population of thymus-dependent lymphocytes which can function as effector cells in ADCC. |
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| Keywords: | To whom requests for reprints should be sent: Department of Surgery 750 Lyons-Harrison Research University of Alabama Medical Center Birmingham Ala. 35294. |
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